Map Drugs: Latvian Products

Map Latvian national medicinal products to RxNorm standard concepts.

When to Use

When asked to map a Latvian product to RxNorm, or create/review a mapping.tsv in a Latvia product folder.

Prerequisites

Refer to the find-concepts skill for how to search for RxNorm concepts, and the map-drugs skill for general mapping principles and the standard workflow.

Resources

• Use validate_all.py to validate Latvia product folders and triage issue-heavy folders.
• Use make list_folder_patterns to summarize repeated presentation patterns before concept search, especially when one product has many pack variants.
• For Latvia folders that mix device families under the same strength/form pattern, use make list_folder_patterns ARGS="... --package-aware" so package_en distinguishes patterns without splitting on pack size.
• Use apply_pattern_mappings.py to expand one mapping decision per Latvia pattern into all matching product_id rows.

Input Files

Each product folder under data/latvia/products/<active_substance>/<product_name>/ contains:

• data_<date>.tsv: Presentation-level data with product_id, original_name, strength, pharmaceutical_form, product_strength (total dose/volume), package_en, and package_size. This is the primary input — read it first.
• info.txt: Product metadata with short_name, active_substance, marketing_authorisation_holder, manufacturer, atc_code, and links to PIL and SmPC

The parent folder name is the active substance (Latin name), and the product folder name is the brand name.

Output Format

Create mapping.tsv in the product folder following the schema in the map-drugs skill. The source ID column is product_id (Latvian product registry ID).

Workflow

Follow the standard mapping workflow in map-drugs. Latvia-specific deviations:

1. Validate:

   Important: make validate_latvia only works at the product level (<substance>/<product>/). Passing a substance-level folder silently returns OK even when product subfolders have issues.

   To triage all products under a substance, use validate_all.py (no args) and grep:

   bash
   1python3 .claude/skills/map-latvia-drugs/validate_all.py 2>&1 | grep "<substance>"

   To validate a single product folder:

   bash
   1make validate_latvia ARGS="data/latvia/products/<substance>/<product>/"

   Use drill-down mode for details:

   bash
   1make validate_latvia ARGS="data/latvia/products/<substance>/<product>/ --details"
   2make validate_latvia ARGS="data/latvia/products/<substance>/<product>/ --details --issue MISSING"

   Issue types: UNMAPPED_FOLDER, MISSING, STALE_MAPPING, NO_CONCEPT, NO_TYPE, BROAD, NO_MAPPING, REVIEW_VOLUME, REVIEW_INJECTION_FORM, DUPLICATE_DATA, DUPLICATE_MAPPING, INCONSISTENT_CONCEPT, INCONSISTENT_TYPE, plus structural validation issues.

2. Read data: Read data_*.tsv first, then info.txt for active substance and brand name. Only check the SmPC link if the data file doesn't provide enough detail for an informed mapping decision.

3. Search: Translate Latin substance names to English before searching (e.g., warfarinum natricum -> warfarin sodium).

4. Apply pattern decisions when multiple rows share the same presentation:

   bash
   1make apply_latvia_patterns ARGS="data/latvia/products/<substance>/<product>/mapping.tsv" <<'EOF'
   2original_name	strength	pharmaceutical_form	product_strength	concept_id	concept_name	concept_code	mapping_type	comment	suggestion
   3CarvedilolHexal 6.25 mg tablets	6.25 mg	Tablet	6,25 mg	19022749	carvedilol 6.25 MG Oral Tablet	200031	EXACT
   4EOF

   For mixed-device folders where package_en matters:

   bash
   1make apply_latvia_patterns ARGS="data/latvia/products/<substance>/<product>/mapping.tsv --package-aware" <<'EOF'
   2original_name	strength	pharmaceutical_form	product_strength	package_en	concept_id	concept_name	concept_code	mapping_type	comment	suggestion
   3Nordimet	10 mg	Solution for injection	10 mg/0,4 ml	Glass pre-filled pen	44506728	methotrexate 25 MG/ML Auto-Injector	1441408	BROAD	RxNorm lacks the matching volume-specific 25 MG/ML auto-injector presentation.	0.4 ML methotrexate 25 MG/ML Auto-Injector
   4Nordimet	10 mg	Solution for injection	10 mg/0,4 ml	Glass pre-filled syringe with safety system	1146757	0.4 ML methotrexate 25 MG/ML Prefilled Syringe	2377333	EXACT
   5EOF

   Backfill missing dates:

   bash
   1make apply_latvia_patterns ARGS="data/latvia/products/<substance>/<product>/mapping.tsv --backfill-dates"

5. Validate and regenerate:

   bash
   1make validate_mapping ARGS="data/latvia/products/<substance>/<product>/mapping.tsv"
   2make generate_mapping_overviews

Suppressions

Confirmed false positives can be suppressed in data/latvia/suppressions.tsv. See the suppressions section in map-drugs for the format. Latvia uses product_id as the ID column.

Latvia-specific Pitfalls

• Latin vs English substance names: Folders use Latin names (e.g., warfarinum_natricum) but RxNorm uses English (e.g., warfarin sodium)
• Products without RxNorm equivalent: Leave concept fields empty, populate suggestion